Focal adhesion kinase

By Targets:	FAK (19) Anaplastic lymphoma kinase (ALK) (2) Apoptosis (2) Autophagy (1) HIV (1) PROTACs (2) Pyk2 (1) VEGFR (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Infection (2) Metabolic Disease (2)

Targets Recommended: FAK ALCAM/CD166

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15358

ALK inhibitor 2	Anaplastic lymphoma kinase (ALK) FAK	Cancer
ALK inhibitor 2 (compound 18) is a potent pyrimidin ALK inhibitor. ALK inhibitor 2 is a potent inhibitor of *testis-specific serine/threonine kinase* 2 (TSSK2; IC₅₀=37 nM) and focal adhesion kinase (FAK; IC₅₀**=5 nM) .

HY-132296

GSK215	FAK PROTACs	Cancer
GSK215 is a potent and selective *PROTAC focal* adhesion kinase (FAK)** degrader with a pDC₅₀ of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect .

HY-15357

ALK inhibitor 1 1 Publications Verification	Anaplastic lymphoma kinase (ALK) FAK	Cancer
ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of *testis-specific serine/threonine kinase* 2 (TSSK2; IC₅₀=31 nM) and focal adhesion kinase (FAK; IC₅₀**=2 nM) .

HY-143407

FAK-IN-3	FAK	Cancer
FAK-IN-3 (Compound 36) is a potent inhibitor of focal adhesion kinase (FAK). FAK-IN-3 not only decreases migration and invasion of PA-1 cells, but also reduces expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis, and no obvious adverse effects. FAK-IN-3 has the potential for the research of ovarian cancer .

HY-117836

FAK-IN-16	FAK	Cancer
FAK-IN-16 (compound OXA-11) is an orally active, selective focal adhesion kinase (FAK) inhibitor with an IC₅₀ of 1.2 pM. FAK-IN-16 inhibits FAK phosphorylation at pFAK[Y397] and pFAK[Y861]. FAK-IN-16 slows tumor growth and reduces tumor vascularity, invasion. FAK-IN-16 potentiates effects of Cisplatin (HY-17394) on tumor cell proliferation and apoptosis in vitro and anti-tumor actions in mice .

HY-128580

FAK inhibitor 2 1 Publications Verification	FAK	Cancer
FAK inhibitor 2 is a potent focal adhesion kinase (FAK) inhibitor with an IC₅₀  of 0.07 nM, with antitumor and anti-angiogenesis activities .

HY-12444

Y15 Maximum Cited Publications 16 Publications Verification FAK Inhibitor 14	FAK	Cancer
Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth.

HY-10460

PF-431396 5+ Cited Publications	Pyk2 FAK	Cancer
PF-431396 is an orally active dual focal adhesion kinase (FAK) and *proline-rich tyrosine kinase* 2 (PYK2) inhibitor, with IC₅₀** values of 2 nM and 11 nM, respectively .

HY-119932

PROTAC FAK degrader 1 4 Publications Verification	PROTACs FAK	Cancer
PROTAC FAK degrader 1 is a selective and potent von Hippel-Lindau-based **focal adhesion kinase (FAK) degrader with an IC₅₀ of 6.5 nM, DC₅₀** of 3 nM .

HY-162034

FAK-IN-17	FAK	Cancer
FAK-IN-17 is a focal adhesion kinase (FAK) inhibitor. FAK-IN-17 possesses anticancer activity against A549 and MDA-MB-231 cell lines with IC₅₀ values of 130 nM and 94 nM .

HY-122844

Ifebemtinib BI-853520; IN-10018	FAK	Cancer
Ifebemtinib (BI 853520) is an orally active and potent **focal adhesion kinase (FAK) inhibitor (recombinant FAK IC₅₀*=1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase* and FES Kinase with IC₅₀s of 900 nM and 1040 nM, respectively .

HY-126410

Petunidin chloride	FAK	Metabolic Disease
Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of **focal adhesion kinase** and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-155440

FAK-IN-15	FAK	Cancer
FAK-IN-15 (Compound 9b) is a focal adhesion kinase (FAK) inhibitor with an IC₅₀ value of 0.2691 nM. FAK-IN-15 has anti-tumor activity with an IC₅₀ value of 1.033 μM against U87-MG cells .

HY-144448

FAK-IN-2	FAK Apoptosis	Cancer
FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC₅₀= 35 nM). FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis .

HY-155439

FAK-IN-14	FAK	Cancer
FAK-IN-14 (compound 8d) is a **focal adhesion kinase(FAK) inhibitor with an IC₅₀ value of 0.2438 nM. FAK-IN-14 induces U87-MG cell early apoptosis** and arrest the cell at the G2/M phase .

HY-120200

YF-452	VEGFR	Cardiovascular Disease Cancer
YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research .

HY-145652

Narmafotinib AMP-945	FAK	Cancer
Narmafotinib (AMP-945) is an inhibitor of the enzyme focal adhesion kinase (FAK, K_D=0.21 nM). Narmafotinib inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC₅₀=7 nM and exhibits low general cellular toxicity (IC₅₀=2.7 μM, MDA-MB-231 cells) .

HY-153697

FAK-IN-10	FAK	Cancer
FAK-IN-10 is an inhibitor of FAK with an IC₅₀ of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC₅₀s of 4.23 and 0.78 μM,respectively .

HY-N1372A

Fangchinoline 4 Publications Verification	HIV FAK Apoptosis Autophagy	Infection Cancer
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-134570

ZINC40099027	FAK	Metabolic Disease
ZINC40099027 is a FAK activator. ZINC40099027 promotes FAK phosphorylation, inducing mucosal healing in murine models. ZINC40099027 can be used for Gastroduodenal ulcer disease research .

Cat. No.	Product Name	Type

HY-156263

LB Broth Base, powder Luria-Bertani Base	Biochemical Assay Reagents
LB Broth Base, powder (Luria-Bertani Base) is generally used to maintain the growth of E. coli. The composition of 1 liter of LB medium is: 10 g peptone, 5 g yeast extract and 5 g NaCl .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126410

Petunidin chloride	Anthocyans Flavonoids Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Solanaceae Disease Research Fields Etunia hybrida (J. D. Hooker) Vilmorin	FAK
Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of **focal adhesion kinase** and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-N1372A

Fangchinoline 4 Publications Verification	Infection Stephania tetrandra S. Moore Alkaloids Monophenols Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Disease Research Fields Menispermaceae	HIV FAK Apoptosis Autophagy
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

Species:	Human (2)
Tag:	Tag Free (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701682

	FAK1 Protein, Human (Sf9, GST) PTK2; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	Human	Sf9 insect cells
	FAK1 is a nonreceptor protein tyrosine kinase that coordinates multiple cellular processes. FAK1 Protein, Human (Sf9, GST) is the recombinant human-derived FAK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of FAK1 Protein, Human (Sf9, GST) is 1052 a.a., .

HY-P702717

	PTK2B Protein, Human (sf9) PTK2B; PTK2B protein tyrosine kinase 2 beta; FAK2, protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; CADTK; CAKB; PTK; PYK2; RAFTK; FADK 2; CAK-beta; protein kinase B; Focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion Focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; PKB; FAK2; FADK2	Human	Sf9 insect cells


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Cat. No.	Product Name	Application	Reactivity

HY-P80816

Phospho-FAK (Tyr576) Antibody PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	WB	Human, Mouse
Phospho-FAK (Tyr576) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 119 kDa, targeting to Phospho-FAK (Tyr576). It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P80877

PYK2 Antibody (YA682) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P	Human
PYK2 Antibody (YA682) is a non-conjugated and Mouse origined monoclonal antibody about 116 kDa, targeting to PYK2 (4B4). It can be used for WB,IHC-P assays with tag free, in the background of Human.

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Focal adhesion kinase

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